ABSTRACT
Klippel-Trenaunay syndrome is a rare non-hereditary congenital abnormality characterized by a clinical triad of soft tissue hypertrophy of extremity, varicosities and cutaneous hemangiomas or lymphongioma. Bleeding per rectum is an uncommon but potentially serious complication. We herein report a case admitted to the gastroenterology ward Postgraduate Medical Institute, Lady Reading Hospital Peshawar, with intermittent haematocezia and symptomatic iron deficiency anemia. The patient did not seek any help for gastrointestinal bleeding until his admission to our unit. He was also having gigantism of his right leg and port wine angiomatous spots on his buttocks and leg. The literature on the evaluation and management on this case is reviewed
ABSTRACT
Lithium remains a mainstay in the acute and prophylactic treatment of bipolar affective disorder. It is used in the augmentation of antidepressant treatment and, less frequently, in the augmentation of antipsychotic treatment of schizophrenia. It is reported to have specific anti-suicidal effects. Thus the effect of Lithium was interesting to study on the glutathione [GSH] level in vivo conditions. Ellman's method has been used to see the effect of lithium on glutathione [GSH] level in whole blood. The time dependent effect of Lithium on the chemical status of glutathione [GSH] was determined in the whole blood [Plasma and cytosolic fraction] of human. The concentration of Glutathione was drastically decreased. The decrease in the glutathione level was concentration and time of interaction dependent, probably due to oxidation of glutathione [GSH] to corresponding disulphide [GSSG]. In this paper the effect of Lithium on the Thiol/GSH level was discussed in vitro, which in principal may present a model of in vivo reaction